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At the Vorholt Lab (Institute of Microbiology, ETH Zurich), researchers are engineering *Escherichia coli* to efficiently utilize green methanol as a sustainable one-carbon feedstock. Using the fermSYS VOC sensor for real-time methanol monitoring, the team gains continuous process insights that accelerate strain development and optimize fermentation strategies—advancing sustainable biomanufacturing and supporting the transition to a circular carbon economy.

Media screening is no longer just about biomass, O₂ and CO₂. By combining the Kuhner TOM system with the fermSYS fermSENSE – MULTI FLOW, volatile organic compounds (VOCs) provide real-time metabolic insights, revealing by-product formation and cellular stress long before endpoint analysis. More data, better decisions, faster process development – transforming a shaker into an intelligent mini-bioreactor.

Smart fermentation for aquaculture: How a VOC sensor could revolutionise the production of innovative tilapia vaccines. In a current development project by W42, artificially designed antigens against two viral fish pathogens are being produced. What makes this special is that: The yeast cells themselves are used directly as a component of fish feed following fermentation. The VOC sensor provides additional information about the physiological state of the culture.

By combining fermSYS’s innovative VOC sensor technology and smart fermentation vison with Bronkhorst’s high-precision flow measurement and control equipment, we are laying the foundations for improved process control, greater efficiency and deeper insights into biological processes.

Monitoring fermentation processes is easy. With the fermSYS Cube, you get a compact, all-in-one solution for measuring, controlling and analysing data from shake flask or laboratory fermentations. The Cube combines all the necessary components in a single device – from the VOC sensor and control software to wireless communication.

Explore how 'Real-time insight into bioprocesses via VOC sensing is becoming reality.' with cutting-edge VOC sensing tech for smarter bioprocessing.

With the fermSYS Buddy a direct, IoT-based coupling of VOC sensors and pump actuators enables dynamic control of the methanol supply, consistently maintaining concentrations within the optimal range.

How the Bioprocess Owner Reclaims Their Day. For years, the daily routine in fermentation production looked the same: put on safety glasses, glove up, walk to the fermenter, take manual samples, bring them to the lab, wait for results—and still make decisions with a degree of uncertainty. What is really happening inside the bioreactor right now? How is the biomass evolving? Are the cells still viable? And most importantly: when is the right moment to intervene? Those days are

Digitalization is increasingly transforming traditional industries — and brewing is no exception. By integrating intelligent sensor technology and data processing into production workflows, breweries can gain deeper process insights, improve efficiency, and significantly reduce production time. One brewery has taken this step by implementing the FermSYS – Brew Buddy (VOC sensor and data processing platform) directly into its production line. Real-Time Monitoring of Exhaust